HCG 5000IU

WHAT IS HCG 5000IU?

Human Chorionic Gonadotropin (HCG 5000IU) is a lyophilized glycoprotein heterodimer hormone comprised of two non-covalently associated subunits: the alpha subunit (92 amino acids, shared across all glycoprotein hormones) and the hormone-specific beta subunit (145 amino acids, responsible for LH/FSH receptor selectivity). Its approximate molecular weight is ~36,700 Da inclusive of glycosylation, with carbohydrate moieties accounting for roughly 30% of total molecular weight. HCG 5000IU is supplied as a sterile, lyophilized white powder intended strictly for in-vitro laboratory research applications.

MECHANISM OF ACTION, LHCGR PHARMACOLOGY

HCG 5000IU functions as a potent agonist at the luteinizing hormone/choriogonadotropin receptor (LHCGR), a Class A G-protein-coupled receptor (GPCR) expressed predominantly in gonadal and adrenal tissues. Its binding affinity at the LHCGR exceeds that of native LH, attributed to its extended beta-subunit C-terminal peptide (CTP), which prolongs receptor engagement and downstream signalling cascades.

Upon LHCGR activation, HCG initiates cAMP-mediated intracellular signalling, activating protein kinase A (PKA) and downstream effectors including the steroidogenic acute regulatory (StAR) protein, a critical rate-limiting factor in androgen biosynthesis.

RESEARCH APPLICATIONS

Leydig Cell Steroidogenesis Models HCG 5000IU is a standard LHCGR agonist tool compound in preclinical Leydig cell research. In vitro models employ HCG to activate the cAMP → PKA → StAR pathway and study androgen biosynthesis mechanisms, providing a reproducible stimulatory signal for testosterone synthesis pathway characterization.

cAMP & PKA Signalling Research As an LHCGR agonist, HCG 5000IU enables investigation of Gs-coupled receptor signal transduction, cAMP second messenger dynamics, and PKA-mediated phosphorylation events in gonadal cell lines.

Corpus Luteum & Progesterone Synthesis Studies Granulosa and luteal cell model systems utilize HCG 5000IU to probe LHCGR-mediated progesterone synthesis pathways, supporting research into luteal phase signalling and ovarian function mechanisms.

Gonadotropin Receptor Pharmacology HCG 5000IU serves as a reference agonist for LHCGR binding affinity studies, receptor desensitization/internalization research, and comparative pharmacology investigations alongside related glycoprotein hormones (LH, FSH, TSH).

PURITY, QUALITY & TESTING

Each lot of HCG 5000IU from Ageless Vitality Peptides undergoes rigorous third-party analytical testing:

• HPLC Analysis, Confirms ≥99% purity and compound integrity
• Mass Spectrometry (MS), Validates molecular weight and structural authenticity
• Certificate of Analysis (COA), Batch-specific documentation available in the COA Vault

All products are manufactured via lyophilization (freeze-drying), yielding a stable crystalline powder optimized for long-term storage and reliable reconstitution in research settings.

STORAGE INSTRUCTIONS

Before Reconstitution (Lyophilized Powder) Store in a cool, dark environment. For short-term storage (days to weeks), refrigeration at 4°C (39°F) is adequate. For long-term storage (months to years), freeze at -80°C (-112°F) to preserve maximum stability.

After Reconstitution Once reconstituted with bacteriostatic water, store at 4°C (39°F), protect from light, and use within 30 days. Do not freeze reconstituted solution.

TECHNICAL SPECIFICATIONS

⚠️ RESEARCH USE ONLY, REGULATORY NOTICE

This product is supplied exclusively as a chemical reagent for in-vitro laboratory research by qualified investigators. HCG is an FDA-regulated biological drug. This compound is not approved, licensed, or intended for human or animal use, therapeutic application, or clinical administration of any kind.

These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Ageless Vitality Peptides is a chemical supplier only, not a compounding pharmacy (503A) or outsourcing facility (503B) as defined under the Federal Food, Drug, and Cosmetic Act. We do not sell to patients.